Adenosine diphosphate ribosylated histones
Copyright policy )Adenosine diphosphate ribosylated histones
When rat liver nuclei were incubated with [adenine-3H]NAD, besides histone 1, histone 2A and especially histone 2B accepted 3H radioactivity. 3H radioactivity was also found on the non-histone proteins and on the small amounts of histones 1 and 3 released into the supernatant during incubation. [14C]Adenine uptake in vivo by liver and thymus nuclei showed radioactivity in histones 1 and 3. After digestion with Pronase and leucine aminopeptidase 14C- or 32P-labelled histone 3 released a serine phosphate-containing nucleotide, which on acid hydrolysis yielded ADP-ribose and serine phosphate. Serine phosphate was also found in the material from the nucleotide peaks from histones 2A and 2B. ADP-ribosylated histones 1 and 3 were more easily released from nuclei than their unmodified forms and showed higher [32P]Pi and [3H]lysine uptakes in vivo [Ord & Stocken (1975) FEBS Meet. Proc. 34, 113-125].
- University of Oxford United Kingdom
Cell Nucleus, Male, Binding Sites, Nucleoside Diphosphate Sugars, Adenine, Ribose, Adenosine Diphosphate Sugars, Thymus Gland, In Vitro Techniques, NAD, Rats, Histones, Liver, Serine, Animals, Hepatectomy
Cell Nucleus, Male, Binding Sites, Nucleoside Diphosphate Sugars, Adenine, Ribose, Adenosine Diphosphate Sugars, Thymus Gland, In Vitro Techniques, NAD, Rats, Histones, Liver, Serine, Animals, Hepatectomy
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