Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases
Copyright policy )UKRI| Mechanistic diversity, post-translational carbamylation, and inhibitor susceptibility in the OXA beta-lactamase family ,
EC| PREDACTED ,
UKRI| South West Biosciences Doctoral Training Partnership (SWBio3) ,
UKRI| DTP Bid Led by Cardiff University ,
UKRI| Carbapenem Antibiotic Resistance in Enterobacteriaceae: Understanding Interactions of KPC Carbapenemases with Substrates and Inhibitors
Hoff, JF; Goudar, KE; Calvopiña, K; Beer, M; Hinchliffe, P; Shaw, JM; Tooke, CL; Takebayashi, Y; Cadzow, AF; Harmer, NJ; Mulholland, AJ; Schofield, CJ; Spencer, J;
Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases
The OXA-48 β-lactamase protects bacteria from carbapenem antibiotics; with activity affected by sequence variation. We show variation to affect susceptibility towards diazabicyclooctane (DBO) inhibitors, dependent upon the inhibitor C2 substituent.
United Kingdom
- University of Exeter United Kingdom
- University of Bristol (UoB) United Kingdom
- University of Bristol
- University of Bath United Kingdom
- University of Bristol United Kingdom
Chemistry
Chemistry
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
selected citations
Citations provided by BIP!
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 1
Average
Average
Average
Green
hybrid
Funded byView all
Related to Research communities