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RSC Medicinal Chemistry
Article . 2024 . Peer-reviewed
License: CC BY NC
Data sources: Crossref
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PubMed Central
Article . 2024
License: CC BY NC
Data sources: PubMed Central
RSC Medicinal Chemistry
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Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2024 English Publisher:Royal Society of Chemistry (RSC)Journal:RSC Medicinal Chemistry, volume 15, pages 2,422-2,439 (eissn: 2632-8682, Copyright policy )Funded by:NIH | Inhibition of MEP pathway...
Authors: Darean Bague; Ruiqin Wang; Dana Hodge; Marwa O. Mikati; Jose S. Roma; Helena I. Boshoff; Allyson L. Dailey; +4 Authors

doi: 10.1039/d3md00642e

pmid: 39026652

pmc: PMC11253873

Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs

Abstract

Isoprene biosynthesis is a point of vulnerability for many pathogens. Building on prior work, we report a novel set of potent compounds that display selectivity for P. falciparum over M. tuberculosis, and act on-target intracellularly.

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Chemistry

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
hybrid