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Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2022 United States English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 13, pages 13,110-13,116 (issn: 2041-6520, eissn: 2041-6539, Copyright policy )Funded by:NIH | Amyloidogenic Antibiotics
Authors: Chelsea R. Jones; Gretchen Guaglianone; Grant H. Lai; James S. Nowick;

doi: 10.1039/d2sc02670h

pmid: 36425497

pmc: PMC9667932

Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives

Abstract

O-Acyl isopeptide prodrug analogues of the antibiotic teixobactin are stable and non-gelating at acidic pH but convert to the corresponding active teixobactin analogues at neutral pH, thus overcoming limitations in intravenous dosing of teixobactin.

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Keywords

Chemistry, Orphan Drug, Rare Diseases, Chemical sciences, 615, 616, Chemical Sciences, Infection

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 6
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Top 10%
Average
Top 10%
Green
gold