Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2022 English Publisher:Royal Society of Chemistry (RSC)Journal:Organic & Biomolecular Chemistry, volume 20, pages 3,988-3,997 (issn: 1477-0520, eissn: 1477-0539,

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Authors: Jinfeng Kang; Todd R. Lewis; Alex Gardner; Rodrigo B. Andrade; Rongsheng E. Wang;

doi: 10.1039/d2ob00610c

pmid: 35503511

pmc: PMC9158539

Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids

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Abstract

Aspidosperma terpenoid alkaloids can be quickly prepared using semisynthesis from naturally sourced tabersonine, featuring multiple oxygen-based substituents on the indole ring such as hydroxy and methoxy groups for cancer-targeted SAR studies.

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Keywords

Aspidosperma, Alkaloids, Plant Extracts, Terpenes, Indole Alkaloids

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