Sennoside A is a novel inhibitor targeting caspase-1
Copyright policy )Sennoside A is a novel inhibitor targeting caspase-1
Sen A decreases caspase-1 activity and P2X7 function, which further leads to NLRP3 and AIM2 inflammasome disassembly and the reduced secretion of IL-1β and IL-18viapyroptosis restraining and NF-κB-involved NLRP3 priming.
- Chengdu University of Traditional Chinese Medicine China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
- Chengdu Institute of Biology China (People's Republic of)
Lipopolysaccharides, Sennosides, Inflammasomes, Caspase 1, Interleukin-1beta, Interleukin-18, NF-kappa B, Carrageenan, Adenosine Triphosphate, Nigericin, Caspases, NLR Family, Pyrin Domain-Containing 3 Protein, RNA, Small Interfering, Reactive Oxygen Species, Peptide Hydrolases
Lipopolysaccharides, Sennosides, Inflammasomes, Caspase 1, Interleukin-1beta, Interleukin-18, NF-kappa B, Carrageenan, Adenosine Triphosphate, Nigericin, Caspases, NLR Family, Pyrin Domain-Containing 3 Protein, RNA, Small Interfering, Reactive Oxygen Species, Peptide Hydrolases
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