Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2022 English Publisher:Royal Society of Chemistry (RSC)Journal:Food & Function, volume 13, pages 9,973-9,987 (issn: 2042-6496, eissn: 2042-650X,

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Authors: Zhendong Liu; Ruizhou Liu; Rui Wang; Jihang Dai; Hui Chen; Jingcheng Wang; Xiaolei Li;

doi: 10.1039/d2fo01304e

pmid: 36056701

Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3

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Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations.

Related Organizations

Qilu Hospital of Shandong University
China (People's Republic of)
Yangzhou University
China (People's Republic of)
Northern Jiangsu People's Hospital
China (People's Republic of)

Keywords

Cartilage, Articular, Flavonoids, Interleukin-6, Tumor Necrosis Factor-alpha, Anti-Inflammatory Agents, NF-kappa B, Antioxidants, Rats, Matrix Metalloproteinase 9, Cyclooxygenase 2, Matrix Metalloproteinase 13, Osteoarthritis, Animals, Humans, Saline Solution, Inflammation Mediators, Cells, Cultured, Serpins

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