PROTACs: past, present and future

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2022 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Society Reviews, volume 51, pages 5,214-5,236 (issn: 0306-0012, eissn: 1460-4744,

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Authors: Ke Li; Craig M. Crews;

doi: 10.1039/d2cs00193d

pmid: 35671157

pmc: PMC10237031

PROTACs: past, present and future

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Abstract

This review highlights important milestones in the evolution of PROTACs, briefly discusses recent lessons about targeted protein degradation, and conjectures on the efforts still needed to expand the toolbox for PROTAC discovery.

Related Organizations

Yale University
United States

Keywords

Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Proteolysis, Ubiquitination

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