Catalytic asymmetric total synthesis of diazabicyclooctane β-lactamase inhibitors avibactam and relebactam

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2022 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 58, pages 10,869-10,872 (issn: 1359-7345, eissn: 1364-548X,

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Authors: Zhi Yang; Yu Chen; Linxi Wan; Xiangling Cen; Pei Tang; Fener Chen;

doi: 10.1039/d2cc04006a

pmid: 36074791

Catalytic asymmetric total synthesis of diazabicyclooctane β-lactamase inhibitors avibactam and relebactam

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Abstract

The first catalytic asymmetric total synthesis of marketed DBO β-lactamase inhibitors avibactam and relebactam has been achievedviaa Rh-catalysed asymmetric hydrogenation along with multiple flow procedures.

Related Organizations

Sichuan University
China (People's Republic of)
Fudan University
China (People's Republic of)

Keywords

Esters, Microbial Sensitivity Tests, Amino Acids, beta-Lactamase Inhibitors, Azabicyclo Compounds, beta-Lactamases, Anti-Bacterial Agents

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