Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
Copyright policy )Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
A new class of arylazopyrazole photoswitchable PROTACs (AP-PROTACs) enables light-triggered degradation of a specific ensemble of protein kinases.
- IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom
- GlaxoSmithKline (United Kingdom) United Kingdom
- Stony Brook University United States
- Imperial College London United Kingdom
- University of Newcastle Australia Australia
Tumor Necrosis Factor Ligand Superfamily Member 14, Light, 1.1 Normal biological development and functioning, Chemistry, Multidisciplinary, Ubiquitin-Protein Ligases, 615, KINASE, 1 Underpinning research, proteolysis targeting chimeras (PROTACs), protein expression, Protein Kinase Inhibitors, LIGASE, TOOLS, Multidisciplinary, Science & Technology, COMPLEX, Organic Chemistry, 540, Chemistry, Physical Sciences, Proteolysis, protein degradation, Intercellular Signaling Peptides and Proteins, Pyrazoles, controlled degradation, KINOME, 03 Chemical Sciences, Protein Kinases
Tumor Necrosis Factor Ligand Superfamily Member 14, Light, 1.1 Normal biological development and functioning, Chemistry, Multidisciplinary, Ubiquitin-Protein Ligases, 615, KINASE, 1 Underpinning research, proteolysis targeting chimeras (PROTACs), protein expression, Protein Kinase Inhibitors, LIGASE, TOOLS, Multidisciplinary, Science & Technology, COMPLEX, Organic Chemistry, 540, Chemistry, Physical Sciences, Proteolysis, protein degradation, Intercellular Signaling Peptides and Proteins, Pyrazoles, controlled degradation, KINOME, 03 Chemical Sciences, Protein Kinases
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