Catalytic mechanism of the colistin resistance protein MCR-1

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 21 Dec 2020 Spain, United Kingdom English Publisher:Royal Society of Chemistry (RSC)Journal:Organic & Biomolecular Chemistry, volume 19, pages 3,813-3,819 (issn: 1477-0520, eissn: 1477-0539,

Copyright policy )Funded by:UKRI | Determining the clinical ..., UKRI | Biocatalysis & Biotra..., UKRI | BB/J014400/1 +3 projects

Authors: Reynier Suardíaz; Emily Lythell; Philip Hinchliffe; Marc van der Kamp; James Spencer; Natalie Fey; Adrian J. Mulholland;

doi: 10.1039/d0ob02566f , 10.26434/chemrxiv.13440179.v1

pmid: 33606866

pmc: PMC8097703

handle: 20.500.14352/94321 , 1983/7bfff700-f580-4b48-962e-43fe01b6a0c7

Catalytic mechanism of the colistin resistance protein MCR-1

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Abstract

Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.

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Spain, United Kingdom

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Keywords

Models, Molecular, /dk/atira/pure/core/keywords/faculty_of_enigneering/school_of_chemistry/inorganic_materials; name=Inorganic & Materials, Colistin, Escherichia coli Proteins, 610, Química, 540, Anti-Bacterial Agents, Chemistry, Zinc, Lipid A, Ethanolamines, /dk/atira/pure/core/keywords/faculty_of_enigneering/school_of_chemistry/physical_theoretical; name=Physical & Theoretical, Drug Resistance, Bacterial, 23 Química, Biocatalysis, Density Functional Theory

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