Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2020 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 56, pages 9,731-9,734 (issn: 1359-7345, eissn: 1364-548X,

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Authors: Lei Wang; Hidenori Okamura; Shigeki Sasaki; Yosuke Taniguchi;

doi: 10.1039/d0cc04240d

pmid: 32815931

Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

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Abstract

Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.

Related Organizations

Kyushu University
Japan

Keywords

Cell Nucleus, Base Sequence, Microscopy, Fluorescence, Humans, RNA, Messenger, Oligonucleotides, Antisense, Telomerase, HeLa Cells

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