Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2020 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 56, pages 9,866-9,869 (issn: 1359-7345, eissn: 1364-548X,

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Authors: Yufeng Xiao; Jia Wang; Lisa Y. Zhao; Xinyi Chen; Guangrong Zheng; Xuan Zhang; Daiqing Liao;

doi: 10.1039/d0cc03243c

pmid: 32840532

pmc: PMC7654701

Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs

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Abstract

Potent and histone deacetylase 3 (HDAC3)-specific PROTAC XZ9002 is reported here.

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Keywords

Proteasome Endopeptidase Complex, Ubiquitin, Ubiquitin-Protein Ligases, Histone Deacetylases, Histone Deacetylase 3, Histone Deacetylase Inhibitors, Catalytic Domain, Cell Line, Tumor, Benzamides, Proteolysis, Humans, Cell Proliferation

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