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2′-Fluoro-c-di-GMP as an oral vaccine adjuvant

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2019 Canada Publisher:Royal Society of Chemistry (RSC)Journal:RSC Advances, volume 9, pages 41,481-41,489 (eissn: 2046-2069,

Authors: Hongbin Yan; Jia Li; Rhonda Kuo Lee; Wangxue Chen; Wangxue Chen;

doi: 10.1039/c9ra08310c

pmid: 35541605

pmc: PMC9076492

2′-Fluoro-c-di-GMP as an oral vaccine adjuvant

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Abstract

2′-F-c-di-GMP was synthesized through the modified H-phosphonate chemistry. 2′-F-c-di-GMP was found to be an effective mucosal vaccine adjuvant, both intranasally and orally.

Country

Canada

Related Organizations

National Academies of Sciences, Engineering, and Medicine
United States
National Research Council Canada
Canada
Brock University
Canada

Keywords

Chemistry

1 Research products, page 1 of 1

Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2′-F-c-di-GMP
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