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A ‘catch-and-release’ receptor for the cholera toxin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2019 Netherlands English Publisher:Royal Society of Chemistry (RSC)Journal:Faraday Discussions, volume 219, pages 112-127 (issn: 1359-6640, eissn: 1364-5498,

Authors: Michael E. Webb; Gemma C. Wildsmith; Diksha Haksar; Clare S. Mahon; Clare S. Mahon; Roland J. Pieters; Jeffrey M. Beekman; +3 Authors

doi: 10.1039/c9fd00017h

pmid: 31313796

A ‘catch-and-release’ receptor for the cholera toxin

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Abstract

Thermoresponsive receptors for the recognition unit of the cholera toxin (CTB) can recognise the protein with nanomolar affinity. An increase in temperature can drastically reduce their avidity, enabling on-demand release of CTB.

Country

Netherlands

Related Organizations

Utrecht University
Netherlands
University of York
United Kingdom
University of Leeds
United Kingdom
Institute of Pharmaceutical Sciences
Switzerland
University Medical Center Utrecht
Netherlands

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Keywords

Cholera Toxin, Polymers, Temperature, G(M1) Ganglioside, Phase Transition, Organoids, SDG 3 - Good Health and Well-being, Cholera, Taverne, Humans, Physical and Theoretical Chemistry, Vibrio cholerae, Protein Binding

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	9
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%