DNA directed damage using a brominated DAPI derivative

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2019 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 55, pages 9,971-9,974 (issn: 1359-7345, eissn: 1364-548X,

Copyright policy )Funded by:NSERC | unidentified

Authors: Elyse M. Digby; Rahul Rana; Mark Nitz; Andrew A. Beharry;

doi: 10.1039/c9cc03942b

pmid: 31367709

DNA directed damage using a brominated DAPI derivative

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Abstract

Conversion of a DNA-binding fluorophore (DAPI) to a photosensitizer via bromination retains high fluorescence and high affinity DNA binding but now produces light-induced reactive oxygen species directed towards DNA resulting in rapid cancer cell death.

Related Organizations

University of Toronto
Canada

Keywords

Indoles, Photosensitizing Agents, Light, Cell Survival, Apoptosis, DNA, Bromine, Proof of Concept Study, Photochemotherapy, A549 Cells, Humans, Reactive Oxygen Species, DNA Damage, Fluorescent Dyes

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