Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2018 English Publisher:Royal Society of Chemistry (RSC)Journal:Organic & Biomolecular Chemistry, volume 16, pages 2,464-2,469 (issn: 1477-0520, eissn: 1477-0539,

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Authors: Bo Fan; Wenxin Dong; Tianyi Chen; Jianlin Chu; Bingfang He;

doi: 10.1039/c8ob00376a

pmid: 29561022

Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design

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Abstract

Conduct structure-guided modification on the “hotspot” of glycosyltransferase UGTBL1 to significantly adjust its regioselectivity toward polydatin production.

Related Organizations

Nanjing University of Science and Technology
China (People's Republic of)
The Synergetic Innovation Center for Advanced Materials
China (People's Republic of)
Center for Advanced Materials
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Keywords

Kinetics, Glycosylation, Bacterial Proteins, Glucosides, Glucosyltransferases, Resveratrol, Mutation, Stilbenes, Bacillus licheniformis, Protein Engineering

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