A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2018 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 54, pages 11,885-11,888 (issn: 1359-7345, eissn: 1364-548X,

Copyright policy )Funded by:VR | unidentified

Authors: Johanna Hörberg; Anna Reymer;

doi: 10.1039/c8cc06550k

pmid: 30288518

A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

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Abstract

We explain, with atomic-level detail, how DNA methylation may contribute to the regulation of biological processes. We show that DNA sequence environment modulates the impact of methylation on the physical properties of the double helix.

Related Organizations

University of Gothenburg
Sweden

Keywords

Models, Molecular, DNA, DNA Methylation, Molecular Dynamics Simulation, Biomechanical Phenomena

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