Novel intramolecular photoinduced electron transfer-based probe for the Human Ether-a-go-go-Related Gene (hERG) potassium channel

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2015 English Publisher:Royal Society of Chemistry (RSC)Journal:The Analyst, volume 140, pages 8,101-8,108 (issn: 0003-2654, eissn: 1364-5528,

Copyright policy )

Authors: Zhenzhen Liu; Yubin Zhou; Lupei Du; Minyong Li;

doi: 10.1039/c5an01974e

pmid: 26526230

pmc: PMC4658274

Novel intramolecular photoinduced electron transfer-based probe for the Human Ether-a-go-go-Related Gene (hERG) potassium channel

- Summary
- Subjects
- Metrics

Abstract

A novel conformation-mediated intramolecular photoinduced electron transfer fluorogenic system based-on naphthalimide fluorophore was established for hERG potassium channel herein. After careful evaluation, probe N4 and N6 showed good activity and may have a promising application in hERG channel imaging and drug cardiotoxicity evaluation.

Related Organizations

Texas A&M University
United States
Shandong Women’s University
China (People's Republic of)
The University of Texas System
United States

Keywords

Models, Molecular, Light, Molecular Structure, Electrons, Ether-A-Go-Go Potassium Channels, Electron Transport, HEK293 Cells, Microscopy, Fluorescence, Humans, Biological Assay, Fluorescent Dyes

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	5
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average