Circular permutation of E. coli EPSP synthase: increased inhibitor resistance, improved catalytic activity, and an indicator for protein fragment complementation

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2014 English Publisher:Royal Society of Chemistry (RSC)Journal:Chem. Commun., volume 50, pages 1,830-1,832 (issn: 1359-7345, eissn: 1364-548X,

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Authors: Xiongfeng, Dai; Manlu, Zhu; Yi-Ping, Wang;

doi: 10.1039/c3cc48722a

pmid: 24402609

Circular permutation of E. coli EPSP synthase: increased inhibitor resistance, improved catalytic activity, and an indicator for protein fragment complementation

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Abstract

Circular permutation can increase an enzyme's inhibitor resistance and is a good indicator for establishing protein fragment complementation.

Related Organizations

State Key Laboratory of Protein and Plant Gene Research
China (People's Republic of)
Peking University
China (People's Republic of)
Peking University
China (People's Republic of)

Keywords

Models, Molecular, Glyphosate, Protein Conformation, Mutation, Biocatalysis, Escherichia coli, Glycine, 3-Phosphoshikimate 1-Carboxyvinyltransferase, Enzyme Inhibitors

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