Structure of matrix metalloproteinase-3 with a platinum-based inhibitor
Copyright policy )Structure of matrix metalloproteinase-3 with a platinum-based inhibitor
An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).
- University of Bari Aldo Moro Italy
- National Research Council Italy
- University of Florence Italy
- Institute of Crystallography Italy
- National Research Council Sri Lanka
platinum based molecules, Binding Sites, crystallographyc structure, Matrix Metalloproteinase Inhibitors, Crystallography, X-Ray, Protein Structure, Tertiary, anticancer drugs, X-ray cristallography; MMP; platinum, Coordination Complexes, Matrix Metalloproteinase 3, MMP3, protein ligand interaction, Platinum, Protein Binding
platinum based molecules, Binding Sites, crystallographyc structure, Matrix Metalloproteinase Inhibitors, Crystallography, X-Ray, Protein Structure, Tertiary, anticancer drugs, X-ray cristallography; MMP; platinum, Coordination Complexes, Matrix Metalloproteinase 3, MMP3, protein ligand interaction, Platinum, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!