Graphene oxide strongly inhibits amyloid beta fibrillation
Copyright policy )Graphene oxide strongly inhibits amyloid beta fibrillation
Since amyloid beta fibrillation (AβF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Aβ fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AβF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AβF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media).our results revealed that GO and their surface proteins inhibit AβF by decreasing the kinetic reaction.
- Amsterdam UMC Netherlands
- University of Groningen Netherlands
- University Medical Center Groningen Netherlands
- University of Amsterdam Netherlands
- University Medical Center Groningen Netherlands
GRAPHITE, Amyloid beta-Peptides, A-BETA-42, Water, Oxides, PROTEIN-NANOPARTICLE INTERACTIONS, AGGREGATION, Microscopy, Atomic Force, TOXICITY, Kinetics, NEURODEGENERATIVE DISEASE, FIBRILLOGENESIS, BACTERIA, Graphite, Adsorption, NANOWALLS, ATOMIC-FORCE MICROSCOPY
GRAPHITE, Amyloid beta-Peptides, A-BETA-42, Water, Oxides, PROTEIN-NANOPARTICLE INTERACTIONS, AGGREGATION, Microscopy, Atomic Force, TOXICITY, Kinetics, NEURODEGENERATIVE DISEASE, FIBRILLOGENESIS, BACTERIA, Graphite, Adsorption, NANOWALLS, ATOMIC-FORCE MICROSCOPY
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