Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung-Hang Leung; Hui Yang; Victor Pui-Yan Ma; Daniel Shiu-Hin Chan; Hai-Jing Zhong; Ying-Wei Li; Wang-Fun Fong; Dik-Lung Ma

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Article . 2012 . Peer-reviewed

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https://dx.doi.org/10.1039/c2m...

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Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:Royal Society of Chemistry (RSC)Journal:MedChemComm, volume 3, page 696 (issn: 2040-2503, eissn: 2040-2511,

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Authors: Chung-Hang Leung; Hui Yang; Victor Pui-Yan Ma; Daniel Shiu-Hin Chan; Hai-Jing Zhong; Ying-Wei Li; Wang-Fun Fong; +1 Authors

doi: 10.1039/c2md00306f

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

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Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Related Organizations

Hong Kong Baptist University
China (People's Republic of)
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