Reengineered epipodophyllotoxin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 48, page 10,416 (issn: 1359-7345, eissn: 1364-548X,

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Authors: Igor V, Magedov; Nikolai M, Evdokimov; Menuka, Karki; Amanda S, Peretti; Dustin T, Lima; Liliya V, Frolova; Mary R, Reisenauer; +8 Authors

doi: 10.1039/c2cc35044k

pmid: 22986348

pmc: PMC3563092

Reengineered epipodophyllotoxin

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Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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New Mexico Institute of Mining and Technology
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Keywords

Models, Molecular, Molecular Structure, Apoptosis, Crystallography, X-Ray, Antineoplastic Agents, Phytogenic, Jurkat Cells, MCF-7 Cells, Humans, Drug Screening Assays, Antitumor, Cell Proliferation, HeLa Cells, Podophyllotoxin

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