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Enantioselective synthesis of levomilnacipran

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 48, page 8,111 (issn: 1359-7345, eissn: 1364-548X, Copyright policy )
Authors: Julien, Alliot; Edmond, Gravel; Florence, Pillon; David-Alexandre, Buisson; Marc, Nicolas; Eric, Doris;

doi: 10.1039/c2cc33743f

pmid: 22767143

Enantioselective synthesis of levomilnacipran

Abstract

A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.

Related Organizations
Keywords

Cyclopropanes, Milnacipran, Stereoisomerism, Antidepressive Agents, Phenylacetates

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
31
Top 10%
Top 10%
Top 10%
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