A concise asymmetric synthesis of (−)-rasfonin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 Netherlands English Publisher:Royal Society of Chemistry (RSC)Journal:Org. Biomol. Chem., volume 10, pages 29-31 (issn: 1477-0520, eissn: 1477-0539,

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Authors: Huang, Yange; Minnaard, Adriaan J.; Feringa, Ben L.;

doi: 10.1039/c1ob06700a

pmid: 22113704

handle: 11370/0e4ce561-0100-48bf-adeb-df1b8380cebc

A concise asymmetric synthesis of (−)-rasfonin

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Abstract

A very efficient total synthesis of the apoptosis inducer (-)-rasfonin has been developed using CuBr/JosiPhos catalyzed iterative asymmetric conjugate addition of MeMgBr and Feringa's butenolide.

Country

Netherlands

Related Organizations

University of Groningen
Netherlands

Keywords

ABSOLUTE STEREOCHEMISTRY, EFFICIENT, LOCALIZATION, Apoptosis, SUBUNITS, Pyrones, ACID, TT-1 RASFONIN, Fatty Acids, Unsaturated, CONTAINING NATURAL-PRODUCT, CONJUGATE ADDITION, TRICHURUS-TERROPHILUS, RAS

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