A tumor mRNA-mediated bi-photosensitizer molecular beacon as an efficient imaging and photosensitizing agent
Copyright policy )A tumor mRNA-mediated bi-photosensitizer molecular beacon as an efficient imaging and photosensitizing agent
A bi-photosensitizer molecular beacon (bi-PS MB) is assembled by coupling two PS molecules, respectively, onto the opposite ends of a single MB. The MB can be triggered by a tumor marker-survivin mRNA. Fluorescence and cytotoxic (1)O(2) generation occur effectively in breast cancer cells, but not in normal cells. Compared with a single-PS MB, a bi-PS MB exhibits much-enhanced properties in the signal-to-background ratio and (1)O(2) generation simultaneously.
- Shandong Normal University China (People's Republic of)
Photosensitizing Agents, Base Sequence, Light, Breast Neoplasms, Fluorescence, Photochemotherapy, Cell Line, Tumor, Neoplasms, Biomarkers, Tumor, Humans, RNA, Messenger
Photosensitizing Agents, Base Sequence, Light, Breast Neoplasms, Fluorescence, Photochemotherapy, Cell Line, Tumor, Neoplasms, Biomarkers, Tumor, Humans, RNA, Messenger
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