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Chemical Communications
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Chemical Communications
Article . 2010 . Peer-reviewed
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Chemical Communications
Article . 2011
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https://dx.doi.org/10.1039/c0c...
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University of Southampton: e-Prints Soton
Article . 2010
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Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2010 United Kingdom English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 46, page 8,043 (issn: 1359-7345, eissn: 1364-548X, Copyright policy )
Authors: Li, Zibo; Cai, Hancheng; Hassink, Matthew; Blackman, Melissa L.; Brown, Richard C.D.; Conti, Peter S.; Fox, Joseph M.;

doi: 10.1039/c0cc03078c

pmid: 20862423

pmc: PMC3230320

Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Abstract

A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an (18)F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Country
United Kingdom
Related Organizations
Keywords

Cyclooctanes, Fluorine Radioisotopes, 540, Radiometry, Chromatography, High Pressure Liquid

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 169
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
169
Top 1%
Top 1%
Top 1%
bronze