Synthesis of MUC1–lipopeptide chimeras

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2010 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 46, page 6,249 (issn: 1359-7345, eissn: 1364-548X,

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Authors: Brendan L, Wilkinson; Lara R, Malins; Candy K Y, Chun; Richard J, Payne;

doi: 10.1039/c0cc01360a

pmid: 20664875

Synthesis of MUC1–lipopeptide chimeras

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Abstract

An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation strategy.

Related Organizations

University of Sydney
Australia

Keywords

Lipopeptides, Vaccines, Synthetic, Molecular Structure, Mucin-1, Antigens, Tumor-Associated, Carbohydrate

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