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Chemical Communications
Article . 2010 . Peer-reviewed
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Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

Authors: Zhimeng, Wu; Xueqing, Guo; Zhongwu, Guo;

Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

Abstract

MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-linked glycopeptides.

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Keywords

Cysteine Endopeptidases, Bacterial Proteins, Carbohydrate Sequence, Glycosylphosphatidylinositols, Molecular Sequence Data, Mucin-1, Biocatalysis, Glycopeptides, Amino Acid Sequence, Aminoacyltransferases

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    30
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
30
Top 10%
Top 10%
Top 10%
bronze