Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models

descriptionPublicationkeyboard_double_arrow_right Article 20 Apr 2010 United Kingdom English Publisher:Oxford University Press (OUP)Journal:Molecular BioSystems, volume 6, pages 1,572-1,575 (issn: 1742-206X, eissn: 1742-2051,

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Authors: Barr, Tom A.; Krembuszewski, Martin; Gupta, Manish; Gray, David; Mareque-Rivas, Juan C.;

doi: 10.1039/c002066d

pmid: 20407668

pmc: PMC3745604

handle: 20.500.11820/8f6e97b9-8a31-47f2-b146-cff81603dc8b

Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models

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Abstract

Abstract We attached the pathogen associated molecular pattern Kdo2-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophagesin vitro and they have potent immunostimulatory activity in vivo.

Country

United Kingdom

Related Organizations

University of Edinburgh
United Kingdom

Keywords

Mice, Lipid A, Adjuvants, Immunologic, Macrophages, Quantum Dots, Escherichia coli, Animals, Hydrophobic and Hydrophilic Interactions, Cell Line

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