Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons
Copyright policy )Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons
A panel of stable [Au(R-C--N--C)(N-heterocyclic carbene)](+) complexes displays prominent in vitro anticancer properties; [Au(C--N--C)(IMe)]CF(3)SO(3) (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.
- University of Hong Kong China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
Carcinoma, Hepatocellular, Coordination Complexes - chemistry - therapeutic use - toxicity, Liver Neoplasms, Methane - analogs and derivatives - chemistry, Mice, Nude, Antineoplastic Agents, Hep G2 Cells, Ligands, Mice, Gold - chemistry, DNA Topoisomerases, Type I, Coordination Complexes, Heterocyclic Compounds, Heterocyclic Compounds - chemistry, Animals, Humans, Computer Simulation, Gold, Topoisomerase I Inhibitors, Methane, Antineoplastic Agents - chemistry - therapeutic use - toxicity
Carcinoma, Hepatocellular, Coordination Complexes - chemistry - therapeutic use - toxicity, Liver Neoplasms, Methane - analogs and derivatives - chemistry, Mice, Nude, Antineoplastic Agents, Hep G2 Cells, Ligands, Mice, Gold - chemistry, DNA Topoisomerases, Type I, Coordination Complexes, Heterocyclic Compounds, Heterocyclic Compounds - chemistry, Animals, Humans, Computer Simulation, Gold, Topoisomerase I Inhibitors, Methane, Antineoplastic Agents - chemistry - therapeutic use - toxicity
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