An unnatural amino acid that mimics phosphotyrosine
Copyright policy )An unnatural amino acid that mimics phosphotyrosine
By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments.
- National University of Singapore Singapore
- National University of Singapore Libraries Singapore
STAT3 Transcription Factor, 330, Carboxylic Acids, Fluorescence Polarization, Isoxazoles, 540, Cell Line, Mice, Animals, Humans, Amino Acids, Phosphotyrosine, Cell Proliferation, Protein Binding
STAT3 Transcription Factor, 330, Carboxylic Acids, Fluorescence Polarization, Isoxazoles, 540, Cell Line, Mice, Animals, Humans, Amino Acids, Phosphotyrosine, Cell Proliferation, Protein Binding
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