Ciguatoxin: developing the methodology for total synthesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2010 English Publisher:Royal Society of Chemistry (RSC)Journal:Natural Product Reports, volume 27, page 1,204 (issn: 0265-0568, eissn: 1460-4752,

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Authors: Minoru, Isobe; Akinari, Hamajima;

doi: 10.1039/b919467n

pmid: 20589300

Ciguatoxin: developing the methodology for total synthesis

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Abstract

Covering: up to 2009 The ciguatoxins are sodium channel toxins from the marine dinoflagellate Gambierdiscus toxicus, isolated in 1984. In this review, we summarize the principal concepts and recently developed methodologies for the synthesis of the ciguatoxins, including C–C bond formation by silylacetylene and cobalt-mediated cyclization.

Related Organizations

National Tsing Hua University
Taiwan
Chiba University
Japan

Keywords

Ciguatoxins, Biological Products, Molecular Structure, Dinoflagellida

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