Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Royal Society of Chemistry (RSC)Journal:Organic & Biomolecular Chemistry, volume 7, page 840 (issn: 1477-0520, eissn: 1477-0539,

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Authors: Teather J, Sundstrom; Amy C, Anderson; Dennis L, Wright;

doi: 10.1039/b819067b

pmid: 19225663

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

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Abstract

Phosphoinositide-3-kinase is a pivotal protein involved in a wide variety of signaling cascades and there has been a great deal of interest in the development of potent and selective inhibitors of this enzyme. In this review, the potency and selectivity of the known inhibitors is presented along with key structural information that helps rationalize the observed trends.

Related Organizations

University of Connecticut
United States

Keywords

Structure-Activity Relationship, Binding Sites, 1-Phosphatidylinositol 4-Kinase, Protein Kinase Inhibitors, Protein Binding

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