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New theophylline-activated Diels–Alderase ribozymes by molecular engineering

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Royal Society of Chemistry (RSC)Journal:Org. Biomol. Chem., volume 7, pages 288-292 (issn: 1477-0520, eissn: 1477-0539, Copyright policy )
Authors: Markus, Petermeier; Andres, Jäschke;

doi: 10.1039/b816726e

pmid: 19109673

New theophylline-activated Diels–Alderase ribozymes by molecular engineering

Abstract

Allosteric ribozymes were developed by rational design and step-wise optimization. These ribozymes accelerate a Diels-Alder reaction between anthracene and maleimide derivatives. The optimized sequence is efficiently activated by theophylline under single and multiple turnover conditions and distinguishes between structurally similar effector molecules.

Related Organizations
Keywords

Base Sequence, Theophylline, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Catalytic, Catalysis

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Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
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