One-pot synthesis of cyclic antifreeze glycopeptides

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications (issn: 1359-7345, eissn: 1364-548X,

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Authors: Masakazu, Hachisu; Hiroshi, Hinou; Manabu, Takamichi; Sakae, Tsuda; Shuhei, Koshida; Shin-Ichiro, Nishimura;

doi: 10.1039/b815917c

pmid: 19294247

One-pot synthesis of cyclic antifreeze glycopeptides

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Abstract

The first cyclic glycopeptides exhibiting significant antifreeze activity by forming hexagonal-bipyramidal ice crystals, denoted cyclic antifreeze glycopeptides (cyclic AFGPs), were constructed by a one-pot synthesis based on the controlled cyclization reaction of pre-formed small linear glycopeptides.

Related Organizations

National Institute of Advanced Industrial Science and Technology
Japan
Hokkaido University
Japan
Hokkaido Bunkyo University
Japan

Keywords

Antifreeze Proteins, Circular Dichroism, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Peptides, Cyclic

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