Cleavage of RNA oligonucleotides by aminoglycosides
Copyright policy )Cleavage of RNA oligonucleotides by aminoglycosides
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
- Monash University Australia
- Monash University, Clayton campus Australia
- University of California, San Diego United States
Base Sequence, Esterification, Molecular Sequence Data, Oligonucleotides, Hydrogen-Ion Concentration, Anti-Bacterial Agents, Kinetics, Aminoglycosides, Models, Chemical, Kanamycin, HIV-1, RNA, Ribosomes, Framycetin, HIV Long Terminal Repeat
Base Sequence, Esterification, Molecular Sequence Data, Oligonucleotides, Hydrogen-Ion Concentration, Anti-Bacterial Agents, Kinetics, Aminoglycosides, Models, Chemical, Kanamycin, HIV-1, RNA, Ribosomes, Framycetin, HIV Long Terminal Repeat
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