Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine
Copyright policy ) Koichiro, Nakamura; Yoshio, Hisaeda; Ling, Pan; Hiroshi, Yamauchi;
Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine
A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(III); As(2)O(3)] into arsenobetaine (AB; Me(3)As(+)CH(2)CO(2)(-)) involves treatment of iAs(III) with native B(12) or biomimetic B(12) in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.
- Nippon Sheet Glass (Japan) Japan
- Kyushu University Japan
- Kitasato University Japan
Vitamin B 12, Arsenic Trioxide, Biomimetics, Vitamin B Complex, Oxides, Glutathione, Arsenicals, Iodoacetic Acid
Vitamin B 12, Arsenic Trioxide, Biomimetics, Vitamin B Complex, Oxides, Glutathione, Arsenicals, Iodoacetic Acid
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