A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications (issn: 1359-7345, eissn: 1364-548X,

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Authors: Stephen J, Roe; Robert A, Stockman;

doi: 10.1039/b804304c

pmid: 18633513

A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

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Abstract

Total syntheses of the potent neurotoxins, environmental hazards, and biochemical probes anatoxin-a and homoanatoxin have been achieved from a common intermediate using a combined two-directional synthesis-tandem reaction strategy which includes key advances in oxidative desymmetrisation, tandem Michael-intramolecular Mannich cyclisations and a new method for deprotection of N-tosyl anatoxin-a.

Related Organizations

University of East Anglia
United Kingdom

Keywords

Cyanobacteria Toxins, Bridged Bicyclo Compounds, Heterocyclic, Tropanes

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