In order to characterize reactions as functions of temperature, pressure (molecular density) and the nature of the species that constitute that molecular density, master equation solutions are required. In this tutorial review, the application of the Multiwell suite of codes to some reactions of interest in atmospheric and combustion chemistry is discussed, with attention given to the details of the molecular and energy transfer values. Uncertainties in data and in structural and energetic molecular parameters combine to assure the need for optimization and collaborative processing of the entire data base when modeling practical systems.