Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 United Kingdom English Publisher:Royal Society of Chemistry (RSC)Journal:Chem. Commun. (issn: 1359-7345, eissn: 1364-548X,

Copyright policy )Funded by:WT | High stability copper com...

Authors: Khan, Abid; Silversides, Jon D.; Madden, Leigh; Greenman, John; Archibald, Stephen J.;

doi: 10.1039/b614557d

pmid: 17220989

pmc: PMC1913474

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

- Summary
- Subjects
- Metrics

Abstract

The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

Country

United Kingdom

Related Organizations

View all View all

Keywords

Models, Molecular, Receptors, CXCR4, Molecular Structure, Crystallography, X-Ray, Flow Cytometry, Chemistry, Jurkat Cells, Microscopy, Fluorescence, Metals, Humans, Protein Binding

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	40
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%