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Article . 2008 . Peer-reviewed
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Chemical Society Reviews
Article . 2008
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https://dx.doi.org/10.1039/b61...
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Fluorine in medicinal chemistry

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 United Kingdom English Publisher:Royal Society of Chemistry (RSC)Journal:Chem. Soc. Rev., volume 37, pages 320-330 (issn: 0306-0012, eissn: 1460-4744, Copyright policy )
Authors: Purser, S; Moore, P; Swallow, S; Gouverneur, V;

doi: 10.1039/b610213c

pmid: 18197348

Fluorine in medicinal chemistry

Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

Country
United Kingdom
Related Organizations
Keywords

Hydrocarbons, Fluorinated, Molecular Structure, Chemistry, Pharmaceutical, Drug Design, Humans, Stereoisomerism

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6K
Top 0.01%
Top 0.01%
Top 0.01%
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