Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex
Copyright policy )Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex
We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 +/- 0.9 base pairs per turn.
- Arizona State University United States
Base Sequence, Molecular Sequence Data, Oligonucleotides, Temperature, Nucleic Acid Hybridization, DNA, Oligonucleotides, Antisense, Microscopy, Atomic Force, Nucleic Acid Denaturation, Oligonucleotide Array Sequence Analysis
Base Sequence, Molecular Sequence Data, Oligonucleotides, Temperature, Nucleic Acid Hybridization, DNA, Oligonucleotides, Antisense, Microscopy, Atomic Force, Nucleic Acid Denaturation, Oligonucleotide Array Sequence Analysis
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