Selective steroid recognition by a partially bridged resorcin[4]arene cavitand

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2005 Italy English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications (issn: 1359-7345, eissn: 1364-548X,

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Authors: CACCIARINI, MARTINA; V. A. AZOV; P. SEILER; H. KUNZER; F. DIEDERICH;

doi: 10.1039/b509990k

pmid: 16244724

handle: 2158/250887

Selective steroid recognition by a partially bridged resorcin[4]arene cavitand

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Abstract

The partially bridged resorcin[4]arene cavitand featuring a cleft-shaped recognition site formed by two anti-quinoxaline bridges and four convergent HO-groups was prepared in three steps and characterised by X-ray crystallography; cavitand was found to be a selective receptor for steroidal substrates in CDCl3, with the best binding observed for steroids with a flat A-ring and two H-bonding sites on rings A and C/D.

Country

Italy

Related Organizations

Leibniz Association
Germany
University of Florence
Italy
Laboratory of Organic Chemistry
Switzerland
Schering AG
Germany
Centre For European Economic Research
Germany

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Keywords

Models, Molecular, Molecular Structure, Steroids, molecular recognition, Resorcinols, Crystallography, X-Ray

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