Stereochemistry of the decarboxylation of glyoxylic acid by yeast pyruvate decarboxylase

Hiran Vegad; Mario Lobell; Stephen Bornemann; David H. G. Crout

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Journal of the Chemical Society Perkin Transactions 1

Article . 2000 . Peer-reviewed

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https://dx.doi.org/10.1039/b00...

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Stereochemistry of the decarboxylation of glyoxylic acid by yeast pyruvate decarboxylase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2000Publisher:Royal Society of Chemistry (RSC)Journal:Journal of the Chemical Society, Perkin Transactions 1 (issn: 1470-4358, eissn: 1364-5463,

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Authors: Hiran Vegad; Mario Lobell; Stephen Bornemann; David H. G. Crout;

doi: 10.1039/b002504f

Stereochemistry of the decarboxylation of glyoxylic acid by yeast pyruvate decarboxylase

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Abstract

Tritiated glyoxylic acid was incubated with pyruvate decarboxylase. The hydroxymethylthiamine diphosphate formed was ozonolysed to give tritiated glycolic acid, the absolute configuration of which was investigated by analysis using glycolate oxidase. The tritiated glycolic acid proved to be racemic. The implications of this result are discussed in relation to models for the mechanism of pyruvate decarboxylase.

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University of Warwick
United Kingdom

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