Thickness shear mode acoustic assay for plasminogen activators

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1998Publisher:Royal Society of Chemistry (RSC)Journal:Analytical Communications, volume 35, pages 25-28 (issn: 1359-7337, eissn: 1364-5536,

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Authors: G. L. Hayward; J. M. Scharer; R. L. Dutton; Z. Zhang; M. Moo Young;

doi: 10.1039/a707538c

Thickness shear mode acoustic assay for plasminogen activators

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Abstract

A micro version of the fibrin plate assay based on acoustic viscosity measurements is presented. The clot dissolution time was correlated with the amount of plasminogen activator in the samples assayed. The standard error observed with streptokinase (27%) was comparable with that of the rapid fibrin plate assay while a higher standard error was observed with tissue plasminogen activator (59%). The higher error was attributed to diffusion effects and to acoustic compression wave resonances. The method is rapid, sensitive and very small quantities of reagents are required.

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