Step-gradient Capillary Electrochromatography

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1997Publisher:Royal Society of Chemistry (RSC)Journal:The Analyst, volume 122, pages 1,087-1,088 (issn: 0003-2654, eissn: 1364-5528,

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Authors: Melvin R. Euerby; Declan Gilligan; Christopher M. Johnson; Melvin R. Euerby; Keith D. Bartle;

doi: 10.1039/a703175k

pmid: 9463960

Step-gradient Capillary Electrochromatography

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Abstract

The analytical benefits of using a step-gradient in capillary electrochromatography (CEC) are demonstrated. The application of step-gradient CEC to the analysis of six diuretics of widely differing lipophilicities was evaluated and shown to result in a marked reduction in the analysis time and an improvement in the peak shape for later-eluting lipophilic components. When the step-gradient approach was performed in an automated mode, the retention time RSD for repeated injections was below 1%.

Related Organizations

Loughborough University
United Kingdom

Keywords

Electrophoresis, Capillary, Feasibility Studies, Reproducibility of Results, Diuretics

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