PEGylated substrates of NSP4 protease: A tool to study protease specificity
Copyright policy )PEGylated substrates of NSP4 protease: A tool to study protease specificity
AbstractHerein we present the synthesis of a novel type of peptidomimetics composed of repeating diaminopropionic acid residues modified with structurally diverse heterobifunctional polyethylene glycol chains (abbreviated as DAPEG). Based on the developed compounds, a library of fluorogenic substrates was synthesized. Further library deconvolution towards human neutrophil serine protease 4 (NSP4) yielded highly sensitive and selective internally quenched peptidomimetic substrates.In silicoanalysis of the obtained peptidomimetics revealed the presence of an interaction network with distant subsites located on the enzyme surface.
- Helmholtz Zentrum München Germany
- University of Wrocław Poland
- Wrocław University of Science and Technology Poland
- University of Gdańsk Poland
Myeloblastin, Humans, Peptidomimetics, Sequence Analysis, DNA, Article, Fluorescent Dyes, Substrate Specificity
Myeloblastin, Humans, Peptidomimetics, Sequence Analysis, DNA, Article, Fluorescent Dyes, Substrate Specificity
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