Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20
Copyright policy )Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20
AbstractMalignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective therapy with less side-effect is very necessary. Herein, we identify a compound named as “331” selectively induced cell death in glioma cells but not in astrocytes. Compound 331 upregulated miR-494 and downregulated CDC20 in glioma cells but not in astrocytes. These results suggest that compound 331 could be a potential drug selectively targeting glioma cells through upregulating miR-494 and downregulating CDC20.
- Peking University China (People's Republic of)
- Peking University China (People's Republic of)
- Air Force General Hospital PLA China (People's Republic of)
- McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA United States
Thiosemicarbazones, Mice, Inbred BALB C, Cdc20 Proteins, Cell Survival, Pyridines, Transplantation, Heterologous, Down-Regulation, Mice, Nude, Apoptosis, Cell Cycle Checkpoints, Glioma, Article, Rats, Rats, Sprague-Dawley, Mice, MicroRNAs, Astrocytes, Animals, Humans, Female, Cells, Cultured
Thiosemicarbazones, Mice, Inbred BALB C, Cdc20 Proteins, Cell Survival, Pyridines, Transplantation, Heterologous, Down-Regulation, Mice, Nude, Apoptosis, Cell Cycle Checkpoints, Glioma, Article, Rats, Rats, Sprague-Dawley, Mice, MicroRNAs, Astrocytes, Animals, Humans, Female, Cells, Cultured
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